Formulation of Dispersible Tablet Based on Extract from Cassia Fistula Leaves and Evaluation of its Anti-Fungal Effect on Heat Cure Acrylic Resin

Abstract

Objective: The objective of this research paper was to investigate the antifungal outcome of dispersible tablets based on cassia fistula leaf extract on acrylic resin infected with candida albicans.
Materials and Methods: This cross-sectional analysis was piloted at the G7 campus of Riphah International University from January 2017–January 2019. For this, the ethanolic extract of cassia fistula leaves was obtained and the excipients for the tablet along with the extract obtained were mixed. This mixture was then proceeded through a sieve to acquire granules which were dried and compressed. Afterward, acrylic discs were prepared and inoculated with candida albicans. These discs were then soaked overnight in three different tablet solutions including the placebo tablet solution. The discs were removed after 24 hours and inoculated into a specific media, Sabouraud Dextrose Agar.
Results: The formulated tablet based on cassia fistula leaf extract was found to be equally effective when compared to the commercially available tablet (Poligrip) showing no growth of candida albicans on the SDA plates
Conclusion: The study concluded that the formulated denture cleansing tablets based on extract obtained from cassia fistula leaves could be used as a prophylactic denture hygiene measure against candida albicans and staphylococcus aureus. Denture cleansing tablets based on natural sources can be equally effective as compared to chemical-based formulations in addition to being not only non-toxic, and non-irritant, but also cost-effective.